Gpr15^tm1.1Litt
Targeted Allele Detail

Summary

• Symbol: Gpr15^tm1.1Litt
• Name: G protein-coupled receptor 15; targeted mutation 1.1, Dan R Littman
• MGI ID: MGI:3815547
• Synonyms: Gpr15^gfp
• Gene: Gpr15 Location: Chr16:58537796-58539433 bp, - strand Genetic Position: Chr16, 34.83 cM
• Alliance: Gpr15^tm1.1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199126
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 1 was replaced by GFP and SV40polyA followed by a loxP-flanked neomycin resistance cassette. The neomycin cassette was later removed by Cre treatment. RT-PCR confirmed the absence of transcript expression in the large intestine lamina propria and spleen. (J:199126)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gpr15 Mutation: 31 strains or lines available

References

• Original: J:199126 Kim SV, et al., GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science. 2013 Jun 21;340(6139):1456-9
• All: 10 reference(s)