Dlg1^tm1Rlh
Targeted Allele Detail

Summary

• Symbol: Dlg1^tm1Rlh
• Name: discs large MAGUK scaffold protein 1; targeted mutation 1, Richard L Huganir
• MGI ID: MGI:3817231
• Synonyms: dlg1^flox, SAP97^flox
• Gene: Dlg1 Location: Chr16:31482261-31692174 bp, + strand Genetic Position: Chr16, 22.4 cM
• Alliance: Dlg1^tm1Rlh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141127
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the exon encoding the carboxy terminus of the first PDZ domain and the amino terminus of the second PZD domain and an frt flanked neo cassette with a 3' loxP site was inserted downstream of this exon. Germ line, flp mediated recombination was used to remove the neo cassette leaving the exon floxed. (J:141127)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlg1 Mutation: 75 strains or lines available

References

• Original: J:141127 Zhou W, et al., GluR1 controls dendrite growth through its binding partner, SAP97. J Neurosci. 2008 Oct 8;28(41):10220-33
• All: 14 reference(s)