Mesp2^tm12Ysa
Targeted Allele Detail

Summary

• Symbol: Mesp2^tm12Ysa
• Name: mesoderm posterior 2; targeted mutation 12, Yukimo Saga
• MGI ID: MGI:3817238
• Synonyms: P2EmB1D
• Gene: Mesp2 Location: Chr7:79460475-79463179 bp, + strand Genetic Position: Chr7, 45.18 cM
• Alliance: Mesp2^tm12Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141112
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Two Tbx6 binding sites contained within the minimal pre-somitic mesoderm enhancer region upstream of exon 1 were replaced with ones containing mutations at site B and site D. A floxed neo cassette inserted upstream of the enhancer region was removed by germ line, cre mediated recombination. (J:141112)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mesp2 Mutation: 30 strains or lines available

References

• Original: J:141112 Yasuhiko Y, et al., Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2. Development. 2008 Nov;135(21):3511-9
• All: 1 reference(s)