Edil3^tm1Tq
Targeted Allele Detail

Summary

• Symbol: Edil3^tm1Tq
• Name: EGF-like repeats and discoidin I-like domains 3; targeted mutation 1, Thomas Quertermous
• MGI ID: MGI:3817261
• Synonyms: Del-1^-, Del1^KO, Del1-LacZ, Edil3^tm1Gpy
• Gene: Edil3 Location: Chr13:88969591-89471342 bp, + strand Genetic Position: Chr13, 45.3 cM, cytoband C3
• Alliance: Edil3^tm1Tq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141063
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first ATG in the exon 1 was inactivated by insertion of a LacZ-Neomycin cassette at the PstI site. LacZ expression was detected in the cranium, brain, vertebral ganglia, gut, and cardiac cushions of E9.5-E11.5 embryos. Endogenous gene inactivation was confirmed by a lack of signal on Northern blots of RNA extracts from brain and lung of homozygote mice. (J:141063)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Edil3 Mutation: 43 strains or lines available

References

• Original: J:141063 Choi EY, et al., Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science. 2008 Nov 14;322(5904):1101-4
• All: 17 reference(s)