Sting1^tm1Gnb
Targeted Allele Detail

Summary

• Symbol: Sting1^tm1Gnb
• Name: stimulator of interferon response cGAMP interactor 1; targeted mutation 1, Glen N Barber
• MGI ID: MGI:3817418
• Synonyms: Sting^-
• Gene: Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
• Alliance: Sting1^tm1Gnb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141011
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.0 kb region encoding 3 exons and part of a fourth was replaced by a floxed neomycin cassette. Gene inactivation was predicted to be disrupted since the transcriptional start site was included in the deletion region. (J:141011)

Expression

In Mice Carrying this Mutation:

46 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sting1 Mutation: 51 strains or lines available

References

• Original: J:141011 Ishikawa H, et al., STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. Nature. 2008 Oct 2;455(7213):674-8
• All: 79 reference(s)