Naip5^tm1Vnce
Targeted Allele Detail

Summary

• Symbol: Naip5^tm1Vnce
• Name: NLR family, apoptosis inhibitory protein 5; targeted mutation 1 Russell E Vance
• MGI ID: MGI:3817439
• Gene: Naip5 Location: Chr13:100348247-100382831 bp, - strand Genetic Position: Chr13, 53.05 cM, cytoband D1-D3
• Alliance: Naip5^tm1Vnce page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141008
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 11 which encodes the entire essential nucleotide binding domain was replaed with a neomycin resistance cassette. (J:141008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Naip5 Mutation: 103 strains or lines available

References

• Original: J:141008 Lightfield KL, et al., Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nat Immunol. 2008 Oct;9(10):1171-8
• All: 11 reference(s)