Isl1^tm2Sev
Targeted Allele Detail

Summary

• Symbol: Isl1^tm2Sev
• Name: ISL1 transcription factor, LIM/homeodomain; targeted mutation 2, Sylvia M Evans
• MGI ID: MGI:3817457
• Synonyms: Isl1^f
• Gene: Isl1 Location: Chr13:116434817-116446225 bp, - strand Genetic Position: Chr13, 64.87 cM, cytoband D2.3
• Alliance: Isl1^tm2Sev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141110
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4, which encodes the homeodomain of the protein product, was floxed by the insertion of a loxP site on one end and a loxP site and frt-flanked neo cassette on the other end. After germline integration, the frt-flanked neo cassette was removed from Isl1^tm4Sev by crossing with FLPe transgenic strain. (J:141110)

Expression

In Mice Carrying this Mutation:	4 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Isl1 Mutation: 36 strains or lines available

References

• Original: J:141110 Sun Y, et al., A central role for Islet1 in sensory neuron development linking sensory and spinal gene regulatory programs. Nat Neurosci. 2008 Nov;11(11):1283-93
• All: 29 reference(s)