Lepr^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lepr^m3Btlr
• Name: leptin receptor; mutation 3, Bruce Beutler
• MGI ID: MGI:3817472
• Synonyms: well-upholstered
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, identified by its phenotype among G3 progeny of an ENU mutagenized male mouse, is a G to A transition at nucleotide position 2421 (variant 1; Genbank accession NM_146146), in the 12th of the gene's 18 exons. It results in the replacement of a tryptophan codon at amino acid position 623 by a stop codon (W623Ter), which truncates the receptor by 539 amino acids at its C terminus. (J:140985)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:140985 Siggs OM, et al., Record for "well-upholstered", updated November 13, 2008. MGI Direct Data Submission. 2008
• All: 1 reference(s)