Tg(PGK1-KITLG*220)441Daw
Transgene Detail

Summary

• Symbol: Tg(PGK1-KITLG*220)441Daw
• Name: transgene insertion 441, David A Williams
• MGI ID: MGI:3817558
• Synonyms: SCF²²⁰, Tg(huSCFh220)441Daw, TgN(PGKhSCF²²⁰)
• Transgene: Tg(PGK1-KITLG*220)441Daw Location: unknown
• Alliance: Tg(PGK1-KITLG*220)441Daw page

Transgene origin

• Strain of Origin: C3H/HeJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(PGK1-KITLG*220)441Daw expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KITLG (4254)

  Kitl	(MGI:96974)

• Mutation details: A 1.3 kb fragment containing a minigene with the human PGK1 promoter, splice donor/splice acceptor (SD/SA) sequence, a human stem cell factor (hSCF or KITLG) cDNA encoding the 220 amino acid isoform, and a polyA sequence was injected into the pronuclei of fertilized C3H/HeJ eggs. (J:32600)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:32600 Majumdar MK, et al., Xenogeneic expression of human stem cell factor in transgenic mice mimics codominant c-kit mutations. Blood. 1996 Apr 15;87(8):3203-11
• All: 8 reference(s)