Glmn^{Gt(OST109778)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Glmn^{Gt(OST109778)Lex}
• Name: glomulin, FKBP associated protein; gene trap OST109778, Lexicon Genetics
• MGI ID: MGI:3817643
• Gene: Glmn Location: Chr5:107696833-107745754 bp, - strand Genetic Position: Chr5, 52.23 cM
• Alliance: Glmn^{Gt(OST109778)Lex} page

Mutation origin

• Mutant Cell Line: OST109778
• Germline Transmission: Earliest citation of germline transmission: J:184206
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The Lexicon Genetics gene trap vector VICTR48, which contains a splice acceptor sequence followed by the neomycin resistance gene and a double polyadenylation signal, has integrated into the first intron of the glomulin gene upstream of the translation initiation site, which resides in the second exon (Genbank accession NM_133248.1). Western blot analysis confirmed the absence of protein expression in the yolk sac. (J:184206)
• Inheritance: Recessive
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST109778	CG529399 ; (MGI Seq Detail)	3' RACE	Chr5:107721703-107744694 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  5 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Glmn Mutation: 35 strains or lines available

References

• Original: J:184206 Tron AE, et al., The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7. Mol Cell. 2012 Apr 13;46(1):67-78
• All: 2 reference(s)