Tg(CD2-Zbtb7b)C8Rbo
Transgene Detail

Summary

• Symbol: Tg(CD2-Zbtb7b)C8Rbo
• Name: transgene insertion C8, Remy Bosselut
• MGI ID: MGI:3817775
• Synonyms: cKrox, ThPOK
• Transgene: Tg(CD2-Zbtb7b)C8Rbo Location: unknown
• Alliance: Tg(CD2-Zbtb7b)C8Rbo page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD2-Zbtb7b)C8Rbo expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Zbtb7b (MGI:102755)

• Mutation details: Coding sequence for the Zbtb7b gene was placed under control of the human CD2 promoter and locus control region. This promoter drives expression in double-postive and single-positive thymocytes and in mature T cells. Three lines (C8, L4, L8) displaying similar phenotypes were established with the C8 line being chosen for further analysis. Transgene expression was confirmed in thymocytes by immunoprecipitation and immunoblotting. (J:97610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:97610 Sun G, et al., The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection. Nat Immunol. 2005 Apr;6(4):373-81
• All: 10 reference(s)