Cdx1^tm1Lhn
Targeted Allele Detail

Summary

• Symbol: Cdx1^tm1Lhn
• Name: caudal type homeobox 1; targeted mutation 1, David Lohnes
• MGI ID: MGI:3817874
• Synonyms: Cdx1-rare^-, RARE
• Gene: Cdx1 Location: Chr18:61151934-61169271 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Cdx1^tm1Lhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86514
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A retinoic acid response element (RARE) lies about 1-kb upstream from the coding sequence of the gene. The response element was replaced by a floxed neo cassette. Chimeric males bearing the targeted allele were crossed with transgenic mice expressing cre-recombinase to remove the neo-cassette. Whole-mount in situ hybridization revealed reduced expression of the gene locus during embryonic development including in the primitive streak phase and during formation of the neuroectoderm. (J:86514)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdx1 Mutation: 13 strains or lines available

References

• Original: J:86514 Houle M, et al., Retinoic acid regulates a subset of Cdx1 function in vivo. Development. 2003 Dec;130(26):6555-67
• All: 1 reference(s)