Eif6^tm1Sbif
Targeted Allele Detail

Summary

• Symbol: Eif6^tm1Sbif
• Name: eukaryotic translation initiation factor 6; targeted mutation 1, Stefano Biffo
• MGI ID: MGI:3817934
• Gene: Eif6 Location: Chr2:155661757-155668845 bp, - strand Genetic Position: Chr2, 77.26 cM
• Alliance: Eif6^tm1Sbif page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a neo cassette. The 50% reduction of protein expression was confirmed by quantitative western blot analysis on heart, spleen, liver, testis, kidney, brain, lung, muscle and skin extracts from heterozygous mice. (J:141257)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eif6 Mutation: 26 strains or lines available

References

• Original: J:141257 Gandin V, et al., Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation. Nature. 2008 Oct 2;455(7213):684-8
• All: 10 reference(s)