Ccm2^tm1Kwhi
Targeted Allele Detail

Summary

• Symbol: Ccm2^tm1Kwhi
• Name: cerebral cavernous malformation 2; targeted mutation 1, Kevin Whitehead
• MGI ID: MGI:3817969
• Gene: Ccm2 Location: Chr11:6496887-6546744 bp, + strand Genetic Position: Chr11, 4.45 cM
• Alliance: Ccm2^tm1Kwhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:146527
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a neomycin resistance cassette followed by a loxP site and then an EGFP gene were all inserted downstream of the last exon (exon 10). Correct targeting was confirmed by genomic PCR. (J:146527)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccm2 Mutation: 48 strains or lines available

References

• Original: J:146527 Whitehead KJ, et al., The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPases. Nat Med. 2009 Feb;15(2):177-84
• All: 5 reference(s)