Lilrb4a^tm1Ttk
Targeted Allele Detail

Summary

• Symbol: Lilrb4a^tm1Ttk
• Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4A; targeted mutation 1, Toshiyuki Takai
• MGI ID: MGI:3818260
• Synonyms: Gp49B^-
• Gene: Lilrb4a Location: Chr10:51367052-51372707 bp, + strand Genetic Position: Chr10, 25.5 cM, cytoband B4
• Alliance: Lilrb4a^tm1Ttk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141234
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the promoter and first exon of the gene locus. Gene inactivation was confirmed by a lack of protein on the surface of bone marrow derived dendritic cells. (J:141234)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lilrb4a Mutation: 30 strains or lines available

References

• Original: J:141234 Kasai S, et al., A novel regulatory role of gp49B on dendritic cells in T-cell priming. Eur J Immunol. 2008 Sep;38(9):2426-37
• All: 5 reference(s)