Scn11a^tm1Mdba
Targeted Allele Detail

Summary

• Symbol: Scn11a^tm1Mdba
• Name: sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, Mark Baker
• MGI ID: MGI:3818305
• Synonyms: Nav1.9^-
• Gene: Scn11a Location: Chr9:119582829-119654522 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
• Alliance: Scn11a^tm1Mdba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141209
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were replaced with a neo cassette eliminating the domain 1, S4 voltage sensor. The replacement causes a frameshift and introduce STOP codons in exon 6. The absence of full-length transcript expression was confirmed by RT-PCR. (J:141209)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn11a Mutation: 88 strains or lines available

References

• Original: J:141209 Ostman JA, et al., GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. J Physiol. 2008 Feb 15;586(4):1077-87
• All: 10 reference(s)