Tdp1^Gt(XD105)Byg
Gene trapped Allele Detail

Summary

• Symbol: Tdp1^Gt(XD105)Byg
• Name: tyrosyl-DNA phosphodiesterase 1; gene trap XD105, BayGenomics
• MGI ID: MGI:3818340
• Gene: Tdp1 Location: Chr12:99850776-99921478 bp, + strand Genetic Position: Chr12, Syntenic
• Alliance: Tdp1^Gt(XD105)Byg page

Mutation origin

• Mutant Cell Line: XD105
• Germline Transmission: Earliest citation of germline transmission: J:127602
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A gene trap vector containing a beta-geo cassette was inserted downstream of exon 10. The absence of protein expression was confirmed by western blot analysis on cortex, cerbellum and spleen extracts. (J:127605)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XD105	CC178359 ; (MGI Seq Detail)	5' RACE	Chr12:99872353-99878580 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  4 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tdp1 Mutation: 53 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:127605 Katyal S, et al., TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J. 2007 Nov 14;26(22):4720-31
• All: 11 reference(s)