Luzp1^tm1Acch
Targeted Allele Detail

Summary

• Symbol: Luzp1^tm1Acch
• Name: leucine zipper protein 1; targeted mutation 1, Alice Chien Chang
• MGI ID: MGI:3818454
• Synonyms: Luzp^-, Luzp1^{tm1(lacZ)Acch}, Luzp-KO/lacZ-KI
• Gene: Luzp1 Location: Chr4:136197072-136282091 bp, + strand Genetic Position: Chr4, 68.8 cM
• Alliance: Luzp1^tm1Acch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141306
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A NcoI-NcoI fragment at the upstream portion of the open reading frame was replaced with an in-frame LacZ-hprt reporter gene. Gene inactivation was confirmed by a lack of protein found on immunoblotting of brain extracts from E12.5 homozygotes. LacZ expression was detected in the neuroepithelium and mysenchymal cells of both the forebrain and hindbrain of E9 homozygote embryos. (J:141306, J:283453)

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Luzp1 Mutation: 77 strains or lines available

References

• Original: J:141306 Hsu CY, et al., LUZP deficiency affects neural tube closure during brain development. Biochem Biophys Res Commun. 2008 Nov 21;376(3):466-71
• All: 2 reference(s)