Aicda^tm4Mnz
Targeted Allele Detail

Summary

• Symbol: Aicda^tm4Mnz
• Name: activation-induced cytidine deaminase; targeted mutation 4, Michel C Nussenzweig
• MGI ID: MGI:3818467
• Synonyms: AID^T140A
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^tm4Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141427
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: The threonine at amino acid position 140 was mutated to an alanine (T140A) by targeted recombination of exon 3. A loxP-flanked neomycin selection cassette was inserted between exons 2 and 3. Immunoblotting of B cell extracts indicated expression of the mutated protein was similar to that of the endogenous protein. (J:141427)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 57 strains or lines available

References

• Original: J:141427 McBride KM, et al., Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med. 2008 Oct 27;205(11):2585-94
• All: 1 reference(s)