Atg16l1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Atg16l1^tm1Aki
• Name: autophagy related 16 like 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3818483
• Synonyms: Atg16L1^delta
• Gene: Atg16l1 Location: Chr1:87683730-87720150 bp, + strand Genetic Position: Chr1, 44.44 cM
• Alliance: Atg16l1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141420
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3, 4 and 5 that encode the coiled-coiled domain of the gene product were replaced with a neomycin resistance cassette. Immunoblotting of homozygote embryonic fibroblast lysate indicated two truncated proteins were produced. Ectopic expression of similar truncated proteins in wild-type embryonic fibroblasts indicated that the truncated proteins do not interfere in a dominant negative manner with autophagy processes. (J:141420)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atg16l1 Mutation: 44 strains or lines available

References

• Original: J:141420 Saitoh T, et al., Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008 Nov 13;456(7219):264-8
• All: 8 reference(s)