Supv3l1^tm1Jkl
Targeted Allele Detail

Summary

• Symbol: Supv3l1^tm1Jkl
• Name: suppressor of var1, 3-like 1 (S. cerevisiae); targeted mutation 1, Jan Klysik
• MGI ID: MGI:3818518
• Synonyms: Supv3L1^tm1-Jkl
• Gene: Supv3l1 Location: Chr10:62264988-62285517 bp, - strand Genetic Position: Chr10, 32.4 cM
• Alliance: Supv3l1^tm1Jkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141467
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: The targeting vector MHPP80o18, which contains an agouti minigene and puromycin resistance cassette, was inserted between exons 7 and 10 via gap repair and disrupts exons 12 through 16 while exons 1 through 10 remain intact. This allele is hypomorphic as determined by western blot analysis of heterozygous tissue extracts. (J:141467)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Supv3l1 Mutation: 42 strains or lines available

References

• Original: J:141467 Pereira M, et al., Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality. Mech Ageing Dev. 2007 Nov-Dec;128(11-12):609-17
• All: 1 reference(s)