Senp1^Gt(XG001)Byg
Gene trapped Allele Detail

Summary

• Symbol: Senp1^Gt(XG001)Byg
• Name: SUMO1/sentrin specific peptidase 1; gene trap XG001, BayGenomics
• MGI ID: MGI:3818522
• Gene: Senp1 Location: Chr15:97936625-97991625 bp, - strand Genetic Position: Chr15, 54.04 cM
• Alliance: Senp1^Gt(XG001)Byg page

Mutation origin

• Mutant Cell Line: XG001
• Germline Transmission: Earliest citation of germline transmission: J:141453
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: A gene trap vector pGT1Lxf, which contains a beta-geo cassette, was inserted into intron 8. The presence of a truncated transcript was confirmed by RT-PCR. (J:141453)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XG001	CC200220 ; (MGI Seq Detail)	5' RACE	Chr15:97964282-97964417 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  31 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Senp1 Mutation: 69 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141453 Cheng J, et al., SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 2;131(3):584-95
• All: 10 reference(s)