Senp2^{Gt(AN0727)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Senp2^{Gt(AN0727)Wtsi}
• Name: SUMO/sentrin specific peptidase 2; gene trap AN0727, Wellcome Trust Sanger Institute
• MGI ID: MGI:3818535
• Gene: Senp2 Location: Chr16:21828234-21868019 bp, + strand Genetic Position: Chr16, 12.98 cM, cytoband B1
• Alliance: Senp2^{Gt(AN0727)Wtsi} page

Mutation origin

• Mutant Cell Line: AN0727
• Germline Transmission: Earliest citation of germline transmission: J:141453
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• The gene trap vector pGT01xr, which contains a beta-geo cassette, was inserted into intron 10. (J:141453)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AN0727	CW989629 ; (MGI Seq Detail)	5' RACE	Chr16:21842499-21850913 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  12 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Senp2 Mutation: 51 strains or lines available

References

• Original: J:141453 Cheng J, et al., SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 2;131(3):584-95
• All: 3 reference(s)