Retnlb^tm1Mer
Targeted Allele Detail

Summary

• Symbol: Retnlb^tm1Mer
• Name: resistin like beta; targeted mutation 1, Marc E Rothenberg
• MGI ID: MGI:3818561
• Synonyms: RELM-beta^-
• Gene: Retnlb Location: Chr16:48637219-48639255 bp, + strand Genetic Position: Chr16, 30.75 cM, cytoband B5
• Alliance: Retnlb^tm1Mer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141524
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Genomic sequence spanning part of exon 1 and all of exon 2 was replaced with a lacZ gene and neo cassette using VelociGene technology. The absence of protein expression was confirmed by immunohistochemistry on colon samples. (J:141524)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Retnlb Mutation: 14 strains or lines available

References

• Original: J:141524 Hogan SP, et al., Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J Allergy Clin Immunol. 2006 Jul;118(1):257-68
• All: 8 reference(s)