Strc^tm1Ugds
Targeted Allele Detail

Summary

• Symbol: Strc^tm1Ugds
• Name: stereocilin; targeted mutation 1, Unite de Genetique des Deficits Sensoriels
• MGI ID: MGI:3818633
• Gene: Strc Location: Chr2:121193729-121211851 bp, - strand Genetic Position: Chr2, 60.37 cM
• Alliance: Strc^tm1Ugds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141421
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed hygro cassette was inserted downstream of exon 3. Germ line, cre mediated recombination was used to remove exon 2, exon 3 and the selection cassette. The absence of protein expression was confirmed by immunohistochemistry on P14 cochlear sensory epithelia. (J:141421)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Strc Mutation: 67 strains or lines available

References

• Original: J:141421 Verpy E, et al., Stereocilin-deficient mice reveal the origin of cochlear waveform distortions. Nature. 2008 Nov 13;456(7219):255-8
• All: 4 reference(s)