Tnfsf13^tm1Pod
Targeted Allele Detail

Summary

• Symbol: Tnfsf13^tm1Pod
• Name: tumor necrosis factor (ligand) superfamily, member 13; targeted mutation 1, Eckhard R Podack
• MGI ID: MGI:3818634
• Synonyms: APRIL^-
• Gene: Tnfsf13 Location: Chr11:69573672-69576610 bp, - strand Genetic Position: Chr11, 42.86 cM, cytoband B4
• Alliance: Tnfsf13^tm1Pod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141374
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of exon 1, exons 2-5 and part of exon 6. Quantitative RT-PCR of splenocyte extracts confirmed gene inactivation without affecting expression of the nearby genes Tnfsf12 and Senp3. (J:141374)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfsf13 Mutation: 70 strains or lines available

References

• Original: J:141374 Xiao Y, et al., APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response. Eur J Immunol. 2008 Nov 14;38(12):3450-3458
• All: 7 reference(s)