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Tnfsf13tm1Pod
Targeted Allele Detail
Summary
Symbol: Tnfsf13tm1Pod
Name: tumor necrosis factor (ligand) superfamily, member 13; targeted mutation 1, Eckhard R Podack
MGI ID: MGI:3818634
Synonyms: APRIL-
Gene: Tnfsf13  Location: Chr11:69573672-69576610 bp, - strand  Genetic Position: Chr11, 42.86 cM, cytoband B4
Alliance: Tnfsf13tm1Pod page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141374
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 1, exons 2-5 and part of exon 6. Quantitative RT-PCR of splenocyte extracts confirmed gene inactivation without affecting expression of the nearby genes Tnfsf12 and Senp3. (J:141374)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfsf13 Mutation:  70 strains or lines available
References
Original:  J:141374 Xiao Y, et al., APRIL (TNFSF13) regulates collagen-induced arthritis, IL-17 production and Th2 response. Eur J Immunol. 2008 Nov 14;38(12):3450-3458
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory