Rhcg^tm1Ibmm
Targeted Allele Detail

Summary

• Symbol: Rhcg^tm1Ibmm
• Name: Rhesus blood group-associated C glycoprotein; targeted mutation 1, Claude Szpirer
• MGI ID: MGI:3818662
• Gene: Rhcg Location: Chr7:79243111-79267405 bp, - strand Genetic Position: Chr7, 45.09 cM
• Alliance: Rhcg^tm1Ibmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141372
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ gene and a floxed neomycin resistance cassette replaced part of exon 3, exons 4-8, and part of exon 9. Founder mice were crossed with a cre-transgenic strain to removed the neomycin cassette. Gene inactivation was confirmed immunoblotting of male genital tract lysates from homozygous mice (J:141372)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rhcg Mutation: 22 strains or lines available

References

• Original: J:141372 Biver S, et al., A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility. Nature. 2008 Nov 20;456(7220):339-43
• All: 1 reference(s)