Hgs^tm2Tkh
Targeted Allele Detail

Summary

• Symbol: Hgs^tm2Tkh
• Name: HGF-regulated tyrosine kinase substrate; targeted mutation 2, Nobuyuki Tanaka
• MGI ID: MGI:3818694
• Synonyms: hrs^loxP
• Gene: Hgs Location: Chr11:120358461-120374805 bp, + strand Genetic Position: Chr11, 84.16 cM
• Alliance: Hgs^tm2Tkh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141391
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 2 through 4 floxed. (J:141391)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hgs Mutation: 40 strains or lines available

References

• Original: J:141391 Tamai K, et al., Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration. Am J Pathol. 2008 Dec;173(6):1806-17
• All: 3 reference(s)