Gt(ROSA)26Sor^{tm3(CAG-luc)Tyj}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(CAG-luc)Tyj}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Tyler Jacks
• MGI ID: MGI:3818723
• Synonyms: Gt(ROSA)26Sor^tm2Tyj, R26^LSL-LSIY, R26^LSL-SIY, Rosa26-LSL-SIY
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(CAG-luc)Tyj} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141383
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing a CAG promoter, a floxed STOP followed by a luciferase gene and sequence encoding the antigen SIYRYYGL (SIY) was inserted into the locus. Cre-mediated recombination is necessary to allow for expression of luciferase/SIYRYYGL under the control of the CAG promoter. (J:141383)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:141383 Cheung AF, et al., Regulated expression of a tumor-associated antigen reveals multiple levels of T-cell tolerance in a mouse model of lung cancer. Cancer Res. 2008 Nov 15;68(22):9459-68
• All: 9 reference(s)