Nckap1l^m1Iri
Chemically induced Allele Detail

Summary

• Symbol: Nckap1l^m1Iri
• Name: NCK associated protein 1 like; mutation 1, Brian M Iritani
• MGI ID: MGI:3818728
• Synonyms: Hem1^-
• Gene: Nckap1l Location: Chr15:103362221-103407237 bp, + strand Genetic Position: Chr15, 58.96 cM
• Alliance: Nckap1l^m1Iri page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis resulted in a single-nucleotide change in exon 13 that changed a CAG (Gln) to TAG (stop), resulting in premature termination at residue 445. Gene inactivation was confirmed by a lack of signal in immunoblots of homozygote splenocyte lysates. (J:141377)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nckap1l Mutation: 53 strains or lines available

References

• Original: J:141377 Park H, et al., A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity. J Exp Med. 2008 Nov 24;205(12):2899-913
• All: 3 reference(s)