Txnip^tm1Rlee
Targeted Allele Detail

Summary

• Symbol: Txnip^tm1Rlee
• Name: thioredoxin interacting protein; targeted mutation 1, Richard T Lee
• MGI ID: MGI:3818743
• Synonyms: Txnip^flox
• Gene: Txnip Location: Chr3:96465273-96469173 bp, + strand Genetic Position: Chr3, 41.93 cM, cytoband F2.2
• Alliance: Txnip^tm1Rlee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141487
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 168 bp upstream of the first ATG codon in exon 1 and an frt flanked neo cassette and second loxP were inserted downstream of exon 1 via homologous recombination. The neo cassette was removed via in vivo flp-mediated recombination. (J:141487)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Txnip Mutation: 49 strains or lines available

References

• Original: J:141487 Yoshioka J, et al., Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 2007 Dec 7;101(12):1328-38
• All: 14 reference(s)