Txnip^tm1.1Rlee
Targeted Allele Detail

Summary

• Symbol: Txnip^tm1.1Rlee
• Name: thioredoxin interacting protein; targeted mutation 1.1, Richard T Lee
• MGI ID: MGI:3818744
• Synonyms: Txnip^null
• Gene: Txnip Location: Chr3:96465273-96469173 bp, + strand Genetic Position: Chr3, 41.93 cM, cytoband F2.2
• Alliance: Txnip^tm1.1Rlee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141487
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was deleted via cre mediated recombination, Northern and western blot analysis confirmed the absence of mRNA and protein expression in the heart. (J:141487)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Txnip Mutation: 49 strains or lines available

References

• Original: J:141487 Yoshioka J, et al., Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 2007 Dec 7;101(12):1328-38
• All: 9 reference(s)