Ret^tm1Giro
Targeted Allele Detail

Summary

• Symbol: Ret^tm1Giro
• Name: ret proto-oncogene; targeted mutation 1, Giovanni Romeo
• MGI ID: MGI:3819163
• Synonyms: ret^C620R
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm1Giro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141658
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions were used to create an amino acid substitution of arginnine for cysteine at position 20 (C620R). A floxed neo cassette inserted downstream of exon 10 was removed by transient cre expression in ES cells. (J:141658)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ret^tm1Giro

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:141658 Yin L, et al., C620R mutation of the murine ret proto-oncogene: loss of function effect in homozygotes and possible gain of function effect in heterozygotes. Int J Cancer. 2007 Jul 15;121(2):292-300
• All: 2 reference(s)