Hexim1^Gt(XB322)Byg
Gene trapped Allele Detail

Summary

• Symbol: Hexim1^Gt(XB322)Byg
• Name: hexamethylene bis-acetamide inducible 1; gene trap XB322, BayGenomics
• MGI ID: MGI:3819173
• Synonyms: HEXIM1^1-312, HEXIM1^{1 to 312}
• Gene: Hexim1 Location: Chr11:103007151-103010551 bp, + strand Genetic Position: Chr11, 66.71 cM
• Alliance: Hexim1^Gt(XB322)Byg page

Mutation origin

• Mutant Cell Line: XB322
• Germline Transmission: Earliest citation of germline transmission: J:141643
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: The gene trap vector pGT0pfs, which contains a beta-geo cassette, was inserted into the locus and results in a truncated product encoding only the first 312 amino acids of the full-length peptide. (J:141643)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XB322	CC144410 ; (MGI Seq Detail)	5' RACE	Chr11:103008250-103008682 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  2 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hexim1 Mutation: 10 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141643 Montano MM, et al., Mutation of the HEXIM1 gene results in defects during heart and vascular development partly through downregulation of vascular endothelial growth factor. Circ Res. 2008 Feb 29;102(4):415-22
• All: 3 reference(s)