Arhgef12^tm1Soff
Targeted Allele Detail

Summary

• Symbol: Arhgef12^tm1Soff
• Name: Rho guanine nucleotide exchange factor 12; targeted mutation 1, Stefan Offermanns
• MGI ID: MGI:3819185
• Gene: Arhgef12 Location: Chr9:42875138-43017069 bp, - strand Genetic Position: Chr9, 24.14 cM, cytoband B
• Alliance: Arhgef12^tm1Soff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141641
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon (nucleotides 8-307 of NM_027144) and part of the 5' UTR were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on liver and other organ extracts. (J:141641)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef12 Mutation: 89 strains or lines available

References

• Original: J:141641 Wirth A, et al., G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nat Med. 2008 Jan;14(1):64-8
• All: 2 reference(s)