Tg(Myh6/tetO-POSTN)22.1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-POSTN)22.1Jmol
• Name: transgene insertion 22.1, Jeffery D Molkentin
• MGI ID: MGI:3819377
• Synonyms: alpha-MHC-Pn
• Transgene: Tg(Myh6/tetO-POSTN)22.1Jmol Location: unknown
• Alliance: Tg(Myh6/tetO-POSTN)22.1Jmol page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6/tetO-POSTN)22.1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  POSTN (10631)

  Postn

  (MGI:1926321)

• Mutation details: The alpha myosin heavy chain fused to a tet-responsive promoter element (tetO) was used to drive repressible cardiac muscle-specific expression of the human gene. (J:140301)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:140301 Oka T, et al., Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 3;101(3):313-21
• All: 2 reference(s)