Telo2^tm1Tdl
Targeted Allele Detail

Summary

• Symbol: Telo2^tm1Tdl
• Name: telomere maintenance 2; targeted mutation 1, Titia de Lange
• MGI ID: MGI:3819389
• Synonyms: Tel2^FLOX
• Gene: Telo2 Location: Chr17:25318544-25334941 bp, - strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Telo2^tm1Tdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141633
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neo site was inserted downstream of exon 2 and a floxed neo cassette downstream of exon 3. Transient cre expression in ES cells was used to remove the neo cassette leaving exon 3 floxed. (J:141633)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Telo2 Mutation: 33 strains or lines available

References

• Original: J:141633 Takai H, et al., Tel2 regulates the stability of PI3K-related protein kinases. Cell. 2007 Dec 28;131(7):1248-59
• All: 2 reference(s)