G6pc2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: G6pc2^tm1Lex
• Name: glucose-6-phosphatase, catalytic, 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3819785
• Gene: G6pc2 Location: Chr2:69041417-69058185 bp, + strand Genetic Position: Chr2, 39.66 cM
• Alliance: G6pc2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141593
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ/neo selection cassette replaced a 3021 bp region of the gene starting from the initiation codon at position 37 in exon 1 and extending through the first 10 bp of the third intron. Gene disruption was confirmed by RNA blotting and by immunohistochemistry. (J:141593)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any G6pc2 Mutation: 24 strains or lines available

References

• Original: J:141593 Wang Y, et al., Deletion of the gene encoding the islet-specific glucose-6-phosphatase catalytic subunit-related protein autoantigen results in a mild metabolic phenotype. Diabetologia. 2007 Apr;50(4):774-8
• All: 9 reference(s)