Sox4^Igt4
Chemically induced Allele Detail

Summary

• Symbol: Sox4^Igt4
• Name: SRY (sex determining region Y)-box 4; Impaired glucose tolerance 4
• MGI ID: MGI:3819788
• Synonyms: Sox4-Y123C
• Gene: Sox4 Location: Chr13:29132902-29137682 bp, - strand Genetic Position: Chr13, 12.87 cM, cytoband A3-A5
• Alliance: Sox4^Igt4 page

Mutation origin

• Strain of Origin: B6.129S4-Insr^tm1Dac/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Male mice heterozygote for the Insr^tm1Dac allele were treated with ENU and their offspring were screened for impaired glucose tolerance. One line derived from this screen was found to have a single A to G mutation at nucleotide position 1,025 of this gene locus. This corresponded to a tyrosine to cysteine substitution at amino acid 123 (Y123C), which lies in the highly conserved HMG-binding domain. Allelic complementation suggests that this is a functionally null allele. (J:141688)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox4 Mutation: 23 strains or lines available

References

• Original: J:141688 Goldsworthy M, et al., Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. Diabetes. 2008 Aug;57(8):2234-44
• All: 2 reference(s)