Nalcn^tm1.1Dren
Targeted Allele Detail

Summary

• Symbol: Nalcn^tm1.1Dren
• Name: sodium leak channel, non-selective; targeted mutation 1.1, Dejian Ren
• MGI ID: MGI:3819820
• Gene: Nalcn Location: Chr14:123514046-123864556 bp, - strand Genetic Position: Chr14, 66.04 cM
• Alliance: Nalcn^tm1.1Dren page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141581
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exon 1. The absence of transcript expression was confirmed by semi-quantitative RT-PCR on E18.5 brain extracts. (J:141581)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nalcn Mutation: 116 strains or lines available

References

• Original: J:141581 Lu B, et al., The neuronal channel NALCN contributes resting sodium permeability and is required for normal respiratory rhythm. Cell. 2007 Apr 20;129(2):371-83
• All: 4 reference(s)