Aip^tm1Bra
Targeted Allele Detail

Summary

• Symbol: Aip^tm1Bra
• Name: aryl-hydrocarbon receptor-interacting protein; targeted mutation 1, Christopher A Bradfield
• MGI ID: MGI:3819941
• Synonyms: Ara9^-, Ara9^deltaCfx
• Gene: Aip Location: Chr19:4164446-4175858 bp, - strand Genetic Position: Chr19, 3.82 cM
• Alliance: Aip^tm1Bra page

Vessel caliber is decreased in Aip^tm1Bra/Aip^tm1Bra fetuses

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141575
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Inversion
• Aip^tm1Bra involves 1 genes/genome features (Aip) View all
• Mutation details: Exons 3-6 were flanked by loxP sites and were inverted to an antisense orientation via homologous recombination (Aip^tm2.1Bra ). This reverses the sequence of the C-terminal tetratricopeptide repeats and should result in the truncation of the protein. A neomycin cassette was also inserted following exon 6 and flanked on either side with Frt sites. The neomycin cassette was removed by mating with FLPeR mice (Gt(ROSA)26Sor^tm1(FLP1)Dym). (J:141575)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aip Mutation: 26 strains or lines available

References

• Original: J:141575 Lin BC, et al., Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem. 2007 Dec 7;282(49):35924-32
• All: 2 reference(s)