Spag9^tm1Ysok
Targeted Allele Detail

Summary

• Symbol: Spag9^tm1Ysok
• Name: sperm associated antigen 9; targeted mutation 1, Katsuji Yoshioka
• MGI ID: MGI:3820229
• Synonyms: Jlp^tm1Ysok
• Gene: Spag9 Location: Chr11:93886917-94016911 bp, + strand Genetic Position: Chr11, 58.9 cM, cytoband C
• Alliance: Spag9^tm1Ysok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141755
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.2 kb fragment of genomic DNA including all ox exon 1 was replaced with a neo cassette via homologous recombination. Western blot analysis of testicular cell lysates confirmed the absence of protein in homozygotes. (J:141755)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spag9 Mutation: 77 strains or lines available

References

• Original: J:141755 Iwanaga A, et al., Ablation of the scaffold protein JLP causes reduced fertility in male mice. Transgenic Res. 2008 Dec;17(6):1045-58
• All: 5 reference(s)