Nfatc3^tm1Grc
Targeted Allele Detail

Summary

• Symbol: Nfatc3^tm1Grc
• Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3; targeted mutation 1, Gerald R Crabtree
• MGI ID: MGI:3820410
• Synonyms: NFATc3^f
• Gene: Nfatc3 Location: Chr8:106785472-106857169 bp, + strand Genetic Position: Chr8, 53.08 cM, cytoband D
• Alliance: Nfatc3^tm1Grc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141917
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. Transient cre expression in ES cells was used to remove the neo cassette leaving exon 3 floxed. (J:141917)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfatc3 Mutation: 71 strains or lines available

References

• Original: J:141917 Cante-Barrett K, et al., Selective role of NFATc3 in positive selection of thymocytes. J Immunol. 2007 Jul 1;179(1):103-10
• All: 5 reference(s)