Cnn2tm1.2Jin
Targeted Allele Detail
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Symbol: |
Cnn2tm1.2Jin |
Name: |
calponin 2; targeted mutation 1.2, Jian-Ping Jin |
MGI ID: |
MGI:3820423 |
Gene: |
Cnn2 Location: Chr10:79824434-79831234 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Cnn2tm1.2Jin page
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Germline Transmission: |
Earliest citation of germline transmission:
J:141867
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: LoxP sites were inserted in introns 1 and 2 an an frt flanked neomycin resistance cassette was inserted downstream of the loxP site in intron 2. Mice were then crossed to Gt(ROSA)26Sor to produce mice with germline deletion of the frt flanked neomycin resistance cassette. These floxed mice (Cnn2tm1.1Jin) were then crossed with Tg(Zp3-cre)93Knw mice. Cre expression results in the germline excision of exon 2. These mice produce no protein product.
(J:141867)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cnn2 Mutation: |
19 strains or lines available
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Original: |
J:141867 Huang QQ, et al., Role of H2-calponin in regulating macrophage motility and phagocytosis. J Biol Chem. 2008 Sep 19;283(38):25887-99 |
All: |
6 reference(s) |
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