Tg(Cela1-cre/ERT2)1Stof
Transgene Detail

Summary

• Symbol: Tg(Cela1-cre/ERT2)1Stof
• Name: transgene insertion 1, Doris A Stoffers
• MGI ID: MGI:3820514
• Synonyms: ElastaseCreERT2, Tg(Ela1-Cre/ESR1)1Stof
• Transgene: Tg(Cela1-cre/ERT2)1Stof Location: unknown
• Alliance: Tg(Cela1-cre/ERT2)1Stof page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Cela1-cre/ERT2)1Stof expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  rat

  Cela1 (24331)

  Cela1

  (MGI:95314)

• Mutation details: A transgenic construct containing the rabbit Beta-globin (RBG) intron, a sequence encoding Cre/ESR1 (Cre recombinase fused to a mutant estrogen receptor ligand-binding domain (ERT2)) under the control of the acinar cell-specific rat elastase 1 (Cela1) promoter, and a rabbit Beta-globin polyadenylation cassette was made and injected into B6SJLF1 oocytes. (J:121254)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cela1 (rat) Summary of all recombinase alleles driven by Cela1. Comparative matrix view of recombinase activities Alliance rat Cela1 gene page

Tumor Data

List all tumor models in MMHCdb carrying Tg(Cela1-cre/ERT2)1Stof

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:121254 Desai BM, et al., Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration. J Clin Invest. 2007 Apr;117(4):971-7
• All: 17 reference(s)