Tg(tetO-Nfatct1*)1Grc
Transgene Detail

Summary

• Symbol: Tg(tetO-Nfatct1*)1Grc
• Name: transgene insertion 1, Gerald R Crabtree
• MGI ID: MGI:3820649
• Synonyms: NFATc1^nuc
• Transgene: Tg(tetO-Nfatct1*)1Grc Location: unknown
• Alliance: Tg(tetO-Nfatct1*)1Grc page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The CMV promoter fused to a tetracycline responsive element was used to drive tetracycline-regulated and ubiquitous expression of a modified Nfatc1 gene that encodes a nuclear-localized protein as a result of nucleotide substitutions that encode alanines instead of the serines normally dephosphorylated by calcineurin. No line information is given. (J:109543)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO-Nfatct1*)1Grc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:109543 Winslow MM, et al., Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell. 2006 Jun;10(6):771-82
• All: 7 reference(s)