Mylk^tm1Mzhu
Targeted Allele Detail

Summary

• Symbol: Mylk^tm1Mzhu
• Name: myosin, light polypeptide kinase; targeted mutation 1, Min-Sheng Zhu
• MGI ID: MGI:3820656
• Synonyms: Mlck^flox, Mylk^tm1Mzhv
• Gene: Mylk Location: Chr16:34565580-34822790 bp, + strand Genetic Position: Chr16, 24.49 cM
• Alliance: Mylk^tm1Mzhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141907
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt flanked neo selection cassette was inserted in intron 25 just upstream of a loxP site. A second loxP site was placed in intron 22. (J:141907)

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mylk Mutation: 103 strains or lines available

References

• Original: J:141907 He WQ, et al., Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology. 2008 Aug;135(2):610-20
• All: 11 reference(s)