Glrx^tm3Ysh
Targeted Allele Detail

Summary

• Symbol: Glrx^tm3Ysh
• Name: glutaredoxin; targeted mutation 3, Ye-Shih Ho
• MGI ID: MGI:3820704
• Synonyms: TTase^-
• Gene: Glrx Location: Chr13:75988004-75998270 bp, + strand Genetic Position: Chr13, 40.95 cM
• Alliance: Glrx^tm3Ysh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141903
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 as well as parts of intron 1 and intron 2 were replaced with a neomycin resistance cassette. No full sized protein is seen in homozygotes although a smaller sized mRNA band is detected. (J:141903)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glrx Mutation: 14 strains or lines available

References

• Original: J:141903 Lofgren S, et al., Effect of thioltransferase (glutaredoxin) deletion on cellular sensitivity to oxidative stress and cell proliferation in lens epithelial cells of thioltransferase knockout mouse. Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4497-505
• All: 2 reference(s)