Ghsr^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Ghsr^tm1.1Lex
• Name: growth hormone secretagogue receptor; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:3821589
• Synonyms: GHS-R^-
• Gene: Ghsr Location: Chr3:27425500-27432159 bp, + strand Genetic Position: Chr3, 10.86 cM
• Alliance: Ghsr^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141985
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre mediated recombination was used to remove exons 1 and 2. The absence of transcript expression in the brain and pituitary was confirmed by real-time PCR. (J:141985)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ghsr Mutation: 27 strains or lines available

References

• Original: J:141985 Verhulst PJ, et al., Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice. Gastroenterology. 2008 Oct;135(4):1267-76
• All: 9 reference(s)