Hbb-b1^MommeD7
Chemically induced Allele Detail

Summary

• Symbol: Hbb-b1^MommeD7
• Name: hemoglobin, beta adult major chain; modifier of murine metastable epialleles, D7
• MGI ID: MGI:3821597
• Synonyms: RBC14
• Gene: Hbb-b1 Location: unknown Genetic Position: Chr7, 54.85 cM
• Alliance: Hbb-b1^MommeD7 page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a T to C substitution at position 757 in the mRNA altering the canonical polyadenylation signal. Northern blot analysis on RNA from fetal liver cells from homozygous and heterozygous mice detected reduced expression of the wild-type transcript and the presence of larger RNA species not seen in wild-type samples. (J:190446)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hbb-b1 Mutation: 7 strains or lines available

References

• Original: J:142335 Ashe A, et al., A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biol. 2008 Dec 19;9(12):R182
• All: 3 reference(s)